含2-三氟甲基苯并咪唑的1,3,4-噻二唑的合成

Synthesis of 1,3,4-Thiadiazole Containing 2-Trifluoromethyl Benzimidazole

2-三氟甲基苯并咪唑-1-乙酰肼在无水乙醇中与芳基异硫氰酸酯反应得到相应的酰氨基硫脲（Ⅲa～Ⅲd）。再于室温条件下，与浓硫酸反应4h，制得2-（2-三氟甲基苯并咪唑-1-亚甲基）-5-芳氨基-1，3，4-噻二唑（Ⅳa～Ⅳd）。目标化合物经元素分析、IR和^1H NMR进行了结构确证。

Aeylthiosemicarbazide （Ⅲa～Ⅲd） were prepared by reaction of 2-trifluoromethyl beazimidazole-1-acetyl hydrazine（1） with aryl isothiocyanate in the presence of anhydrous ethanol. Then 2-（2-trifluomethyl benzimidazole-1- methylene）-5-arylamino-1,3,4- thiadiazole （Ⅳa～Ⅳd） were synthesized by cyclization of Ⅲa～Ⅲd in concentrated H2SO4 at 20℃ for 4h. The structures of the products were confirmed by elemental analysis, IR and ^1H NMR spectroscopy.