基于FKBP12结构的药物发现:L-1,4-噻嗪-3-羧酸衍生物的设计、合成及其神经营养活性
摘要
以神经亲免素FKBP12为靶点,基于FKBP12,FK506与Calcineurin的复合物晶体结构,设计、合成和筛选能够特异地靶向FKBP12的只具有促神经生长作用的功能而不影响免疫系统的新结构神经退行性疾病治疗药物.结果显示化合物N308作为一种促神经生长和保护的候选药物具进一步开发的前景.
出处
《中国科学（B辑）》
CSCD
北大核心
2006年第6期522-533,共12页
Science in China(Series B)
基金
国家重点基础研究发展规划(批准号:G1998051107)
国家高科技计划(批准号:2002AA233051)资助项目
参考文献13
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