肾上腺髓质素在肺癌患者中的表达及其临床意义

The Expression and Clinical Significance of Adrenomedulin in Patients with Lung Cancer

目的：探讨肾上腺髓质素(ADM)在肺癌患者中的表达及其与肺癌的病理类型及分期的关系。方法：采用放射免疫法,测定20例健康人、24例非肺癌患者及61例肺癌患者血浆中ADM的含量。结果：健康对照组血浆ADM含量为30．25±8．12pg/L,肺癌组血浆ADM含量为40．17±19．23pg/L,两者相比有显著差异(P＜0．05)；非肺癌组血浆ADM含量为27．94±6．75pg/L．与肺癌组相比有显著差异(P＜0．01)；小细胞肺癌组与非小细胞肺癌组相比,血浆ADM含量无显著差异(P＞0．05)；Ⅰ～Ⅲ期肺癌组血浆ADM水平与Ⅳ期肺癌组相比有显著差异(P＜0．05)。结论：ADM在肺癌患者血浆中的表达水平增高,且ADM的表达水平与肺癌的分期及有无远处转移相关,与肺癌的病理类型无关。检测血浆ADM水平对肺癌的诊断及分期具有一定的临床价值,为肺癌的诊断提供了一种新的方法。

Objective：To investigate the expression level of adrenomedulin（ADM） in lung cancer patients,the relationship between ADM and the pathological type and stage of lung cancer. Methods：We determined the content of ADM in plasma of 20 healthy adults, 24 non-lung cancer patients and 61 lung cancer patients by use of radioimmunoassay. Results： The content of ADM in the plasma of healthy control group was 30. 25 ± 8. 12 pg/L,lung cancer group was 40. 17 ± 19. 23 pg/L,there was significant difference between them（P〈0. 05） ;The content of ADM in the plasma of non-lung cancer group was 27. 94 ± 6. 75 pg/L, compared with lung cancer group, there was significant difference（P〈0.01 ）;Small cell lung cancer group compared with non-small cell lung cancer group, the content of ADM in plasma had no signifieant difference（P;〉0.05） ;Ⅰ-Ⅲ stage of lung cancer group compared with Ⅳ stage group, the content of ADM in plasma had significant difference（P〈0. 05）. Conclusion： The expression level of ADM in plasma of lung cancer increased, the expression level of ADM was correlated with the stage of lung cancer and distant metastasis, No correlation was found between ADM level and the pathological type of lung cancer. Therefore, detecting ADM in plasma had great value in lung cancer diagnosis and staging, and provided a new way to lung cancer diagnosis.