微波凝固联合肝动脉化疗栓塞治疗肝内胆管细胞癌27例分析

Analysis of Percutaneous Microwave Coagulation Therapy with Transcatheter Arterial Chemoembolization for Intrahepatic Cholangiocarcinoma in 27 Cases

目的：探讨经皮微波凝固(PMCT)联合肝动脉化疗栓塞(TACE)治疗肝内胆管细胞癌(IHCC)的疗效和机制。方法：对27例未经任何治疗、由肝活检病理证实的IHCC在实时超声引导下行PMCT,再联合TACE,根据治疗后肿瘤的坏死和复发情况,决定是否重复PMCT或TACE。结果：治疗后CA199转阴率44．4%,肿瘤平均缩小率51．4%,肿瘤完全坏死率56．7%,中位生存期18个月,1年生存率66．7%,2年生存率22．9%。结论：PMCT联合TACE治疗IHCC是一种安全、有效的方法。

Objective：To study the efficacy and possible mechanism of percutaneous microwave coagulation therapy （PMCT） combined with transcatheter hepatic arterial chemoembolization（TACE ） in treating intrahepatic cholangiocarcinoma （IHCC）. Methods：A total of 27 histological proved I HCC were treated with ultrasound-guided PMCT, and then followed by TACE. If tumor necrosis was not complete or recurrence was detected, repeated PMCT or TACE was performed. Results： After treatments, the rate of normalized CA199 was 44. 4%, average tumor shrinkage was 51.4%, complete tumor necrosis was 56.7%, median survival time was 18 months, 1 year and 2 year survival rates was 66. 7% and 22. 9%, respectively. Conclusion：The combination of PMCT and TACE therapy for IHCC is a safe and effective modality.