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聚乙二醇干扰素治疗HBeAg阴性乙型肝炎

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摘要 我国是HBV感染高中流行区,近年HBeAg阴性乙型肝炎在慢性乙肝患者中所占比例逐年上升。我国资料表明37%~54%的临床肝硬化、晚期肝病患者多为HBeAg阴性乙肝,这类肝炎患者对目前治疗方案的持续应答率低,临床转归很差。现在抗病毒治疗仍是最主要的治疗措施,我院从2004年3月-2005年3月对32例HBeAg阴性乙型肝炎患者分别进行了聚乙二醇干扰素和普通干扰素治疗,现将结果报告如下。
出处 《中国临床医学》 北大核心 2006年第6期959-959,共1页 Chinese Journal of Clinical Medicine
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  • 1Sandler SR, Karo W, ed. Polymer Syntheses. New York: Academic Press, 1980, 3. 138-161.
  • 2Katre NV, Knauf MJ, Laird WJ. Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model. Proc Natl Acad Sci USA, 1987, 84: 1487-1491.
  • 3Carpenter CP, Woodside MD, Kinkead ER, et al. Response of dogs to repeated intravenous injection of polyethylene glycol 4000. Toxicol Appl Pharmacol, 1971, 18: 35-40.
  • 4Abuchowski A, Davis FF. Soluble Polymer-enzyme adducts. In: Holcenberg JC, Ed. Enzymes as drugs. New York: Wiley and Sons Inc, 1981. 367-383.
  • 5Knauf MJ, Bell DP, Hirtzer P, et al. Relationship of effective molecularsize to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers. J Biol Chem, 1988, 263: 15064-15070.
  • 6Savoca K, Wieder K. Modified enzymes with unique properties. In: GB Broun, et al. Eds. Enzyme-Polyethylene glycol adducts. Vol 4. New York: Enzyme Engineering, Plenum Press. 1978. 169-173.
  • 7Mur RE. Preliminary clinical results of combination pegylated interferon α-2b plus ribavirin. In: 35th Annual meeting of the European Association for the Study of the liver. 2000, 19.
  • 8Heathcote EJ, Pockros P, Fried M, et al. The pharmacokinetics of pegylated-40 K interferon in chronic hepatitis C patients with cirrhosis. Gastroen-terology, 1999, 116(Pt2): 3190.
  • 9Glue P. Clinical pharmacology of pegylated Interferon α-2b. In: 35th Annual meeting of the European Association for the Study of the Liver. 2000, 13.
  • 10Schiffman M, Pockros PJ, Reddy RK, et al. A controlled, randomized multicenter, descending dose phase Ⅱ trial of pegylated interferon α-2a(PEG) vs standard interferon α-2a(IFN) for treatment of chronic hepatitis C. Gastroenterology, 1999, 116(Pt2): 1275.

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