短期胰岛素泵强化治疗初诊2型糖尿病的临床观察

The Clinical Observation of Short-term Continuous Subcutaneous Insulin Infusion Treatment in Newly-diagnosed Type 2 Diabetic Patients

目的：探讨短期胰岛素泵强化治疗对初诊的2型糖尿病患者血糖的控制情况及影响治疗成功的相关因素。方法：对18例初诊的2型糖尿病患者进行为期2周的胰岛素泵强化治疗。分析比较治疗前、后空腹及餐后2h血糖、糖化血红蛋白、甘油三酯、体重指数的变化,并对相关因素进行分析；随访长期的血糖控制情况。结果：2周的胰岛素泵治疗可使所有患者的血糖快速、稳定下降；13例合并降脂治疗者甘油三酯明显下降；治疗前后体重指数无变化；糖化血红蛋白也有明显下降；11例患者在用胰岛素泵治疗后采用饮食控制及运动锻炼,随访超过6个月仍保持血糖正常。年龄较轻、强化期间胰岛素用量小者,则治疗成功率较高。结论：时初发2型糖尿病患者,短期胰岛素泵强化治疗可使部分患者仅通过饮食控制及运动锻炼即能获得良好的血糖控制。

Objective：To investigate the clinical outcome of short-term intensive insulin treatment on long-term glycemic control in newly diagnosed type 2 diabetes patients and discuss the affecting factors. Methods： 18 newly diagnosed type 2 diabetes patients were treated with CSII for 2 weeks. FBG, PG2h, HbAlc,TG,BMI were assessed before and after the insulin treatment. After the treatment,all patients were followed up for their glycemic control level. Results： The optimal glycemic control in all patients were acquired rapidly and stably by CSII. TG level decreased significantly in thirteen patients combined with lipidcontrol agents. BMI had no significant changes before and after CSII. The significant decrease of HbAlc was observed. The gly cemic level of Eleven patients maintained normal on diet and movement more than six months. And find the younger and less of the insulin dosage during the CSII, the higher success rate is. Conclusion：Short-term intensive insulin therapy can induce longterm glycernic control in newly diagnosed type 2 diabetes patients.