摘要
5-(4-吡啶基)-1,3,4-唑-2-硫酮(C7H5N3OS)是异烟肼与二硫化碳发生加成闭环反应时获得。文章初步讨论了反应历程,提出该反应的机理是亲核加成,并通过IR谱和NMR谱对标题化合物的结构进行了表征,热稳定性测试表明:该化合物在506℃时完全分解。
The title compound （5-（4-pyridyl）-l, 3,4-oxadiazole-2-thiol） was synthesized by the ring-closing reaction of isoniazide with carbon bisulfide, and the reaction course was discussed preliminarily. The mechanism of this reaction is nucleophilic addition. The compound was characterized by Fourier transform infrared （FTIR） spectrometry and nuclear magnetic resonance （NMR）. The thermal analytical data indicate that the compound was decomposed completely at the temperature of 506 ℃.
出处
《光谱学与光谱分析》
SCIE
EI
CAS
CSCD
北大核心
2006年第12期2229-2231,共3页
Spectroscopy and Spectral Analysis
基金
江苏省自然科学基金项目(BK2005130)资助
关键词
闭环反应
异烟肼
结构表征
Ring-closing reaction
Isoniazide
Structure characterization
