竹红菌甲素与肌红蛋白和血红蛋白相互作用的同步荧光光谱研究

Study on Interaction between Hypocrellin A and Hemoglobin or Myoglobin Using Synchronous Fluorescence Spectra

利用同步荧光光谱方法研究了竹红菌甲素(HA)对肌红蛋白和血红蛋白构象的影响。结果表明,HA能够使肌红蛋白和血红蛋白的构象发生改变,导致蛋白质分子中色氨酸和酪氨酸残基所处微环境由原来的疏水环境不同程度地向亲水环境转变。

The effects of hypocrellin A （HA） on the configrmational changes of hemoglobin and myoglobin were studied using synchronous fluorescence spectroscopy, The results indicated that HA can change the conformation of these two proteins, leading to the change in the micro-environment of tryptophane and tyrosine residues from hydrophobic environment to hydrophilic environment to different extent.