摘要
肝脏在受到损害或切除之后,可以显示出强大的再生能力。肝再生这一现象早已被人们发现并研究。肝脏再生的启动因素有哪些,又是如何适时终止的?在肝再生过程中,哪些基因的表达发生了变化?哪些信号通路参与了肝再生过程?这些问题一直是研究者关注的焦点。本文将对肝再生研究的这些热点问题进行综述。
Liver has the powerful capacity to regenerate after injury or resection. This capacity was realized and studied for thousands of years. Liver regeneration is a very complex process which is involved in a large number of genes, growth factors and signal pathways. What triggers liver regeneration after the injury or resection of the liver？ How dose the liver regeneration stop properly？ How dose the hepatocyte proliferate and differentiate？ We will give a review about these focused questions here.
关键词
肝再生
动物模型
基因表达
生长因子
信号通路
干细胞
liver regeneration, animal model, gene expression, growth factor, signal pathway, stern cell
