复方普鲁卡因对小鼠、蟾蜍神经干阻断作用的实验研究

THE EXPREIMENTAL STUDY OF PROCAINE COMPOUND BLOCKING ACTION IN MOUSE AND TOAD NERVE TRUNK

复方普鲁卡因对小鼠坐骨神经干麻醉作用：ＥＤ５０量是１．３４ｍｇ，麻醉效力是普鲁卡因的１．９６１倍，是利多卡因的０．７５４倍，０．９５％复方普鲁卡因麻醉持续时间长于同浓度普鲁卡因，Ｐ〈０．０５，短于同浓度的利多卡因，Ｐ〈０．０１。１．９％复方普鲁卡因１０μｌ（２９．８３×１０＾４μｍｏｌ／Ｌ）对蟾蜍坐骨神经标本麻醉作用：５分钟内动作电位衰减率近１７±３．６％（Ｘ↑－±ＳＤ），而同浓度。

The anesthesia action of Procaine Compound ( Pco. ) in mouse sciatie nerve: ED50was 1.34mg; The anesthesia efficiency wasl.961 times of Procaine ( P ) and 0.754 times of Lidocaine ( L ) ; The anesthesia maintenance time of 0.95% Pro.was longer than that of the same concentration P(P<0.05)and shorter than that of the same concentration L ( P<0.01 ) .The anesthesia action of 1.9% Pco.10ul ( 29.83×104 umol/L) in tode sciatic nerve preparation. The attenution rate of Action Potential ( Apc ) approximated 17±3.6% (X±SD) in 5 minutes.That of the same dose and concentration of P.andL. were 19.2±5.1%, 21.1±3.0% respectively in 7 minutes.The results show that the anesthesia action of 1.9% Pco.in tode sciatic nerve trunk is powerful than that of P and L.