摘要
40只豚鼠分成4组,在下切牙区龈沟分别灌注G-菌内毒素(LPS)、G+菌脂磷壁酸(LTA)、龈下菌斑(PL)及生理盐水(NS),於1、2、3、6、8周分批处死观察。结果:NS对照组除1、2周牙龈出现少量炎症细胞外,未见其他异常;LPS组1周很快出现牙龈炎症和明显骨吸收,4、5周炎症渐消退并有新骨形成;LTA组菌斑和牙石沉积明显,而炎症与骨吸收较弱,3周即渐恢复;PL组既见菌斑牙石形成,又有炎症反应及骨吸收,持续时间较长,6、8周仍见轻度炎症。它们作用于牙周组织的不同特点,为进一步阐明牙周病的发病机理提供实验依据。
Abstract Guinea pigs were divided into 4 groups.The gingival sulcus of 2 mandibular incisors were irrigated with LPS (Lipopolysaccharide),LTA (Lipoteichoic acid),PL(Subgingival plaque) and NS(Normal saline solution)respectively.2 animals were sacrificed in group of 5 successively at 1,2,3,6,8 week after irrigation. Microscopic examination demonstrated: Only a few penetration of inflammatory cells lay in the gingival tissue in NS control group. Significant infiltrate associated with evident crestal resorption were noted at 1st week and active remodeling took place at 4th,5th week in LPS group. Enhancing accumulations of plaque calculus with weak inflammation could be seen in LTA group. Not only accumulations of plaque and calculus but also penetration of inflammation with resorption of bone were seen in PL group.Their effects on the periodontal tissue of Guinea pig showed evident different. These findings served further expression the possible mechanisms of periododntal diseases.
出处
《上海口腔医学》
CAS
CSCD
1996年第4期203-206,共4页
Shanghai Journal of Stomatology
基金
国家自然科学基金