卵巢癌患者血清中RANTES的浓度水平及其临床意义

Concentration levels of serum RANTES in patients with ovarian cancer and their clinical significance

目的评价受激活调节正常T细胞表达和分泌因子(regulateduponactivationnormal Tcellexpressedandsecreted,RANTES)在卵巢癌患者血清中的浓度水平及其临床意义。方法收集我院43例恶性卵巢癌(按FIGO分期,Ⅰ期17例,Ⅱ期6例,Ⅲ期14例,Ⅳ期6例)、10例良性卵巢囊肿和15例正常健康妇女血清。采集手术前患者血清标本,用酶联免疫吸附实验(ELISA)检测血清RANTES浓度。结果恶性卵巢癌妇女血清中RANTES浓度水平中位数为55ng/ml,显著高于良性卵巢囊肿的37ng/ml和正常健康妇女组的35ng/ml(P<0.01)。23例Ⅰ期和Ⅱ期患者血清RANTES浓度水平明显低于Ⅲ期和Ⅳ期患者(P<0.05),RANTES浓度水平随病情严重程度而升高,而且存在肿瘤残余的患者RANTES高于无肿瘤残余者(P<0.05)。结论卵巢癌患者血清RANTES浓度与疾病的严重程度相关,可作为鉴别恶性卵巢癌与良性囊肿的有用的指标。

Objective To assess the clinical significance of serum Regulated upon Activation Normal T-cell Expressed and Secreted （RANTES） levels in patients with ovarian cancers. Methods Preoperative serum RANTES levels were measured in women with malignant ovarian cancer （n =43 ）, benign ovarian cysts （ n = 10）, or normal controls （ n = 15 ） using enzyme-linked immunosorbent assay. Results The serum RANTES concentration was significantly elevated in the ovarian cancer patients （median 55 ng/ml） compared with the benign ovarian cyst patients（37 ug/ml） and controls （35 ng/ml） （P 〈0. 01 ）. The serum RANTES levels were correlated with the stage of disease and the extent of residual tumor mass. Conclusion The serum RANTES levels in patients with ovarian cancers are correlated with the extent of the disease. It can be a useful biomarker for differentiating benign ovarian tumors from malignancy.