OLF和LFP方案治疗晚期胃癌的临床疗效

Clinical efficacy of OLF regimen and LFP regimen in treatment of the patients with advanced gastric carcinoma

目的观察OLF和LFP方案治疗晚期胃癌的临床疗效。方法48例晚期胃癌患者分为OLF组和LFP组进行化疗。其中OLF组(草酸铂、亚叶酸钙、5-Fu)26例,LFP组(顺铂、亚叶酸钙、5-Fu)22例,对比观察两种方案的疗效和毒性。结果OLF方案治疗晚期胃癌有效率为53.8%,LFP方案为45.5%,两组比较差异无显著性(P>0.05)。OLF组中位生存期9.5个月,LFP组6.5个月。恶心、呕吐、食欲下降发生率两组间比较差异有显著性(P<0.01)。结论OLF和LFP两种方案均是治疗晚期胃癌较为有效的化疗方案,其有效率差异无显著性,但OLF方案患者耐受性好,生活质量高,值得临床推广应用。

Objective To observe the clinical efficacy of OLF （oxaliplatin plus CF and 5-Fu） regimen and LFP （ DDP plus CF and 5-Fu） regimen in treatment of the patients with advanced gastric carcinoma. Methods Forty-eight patients with advanced gastric carcinoma received chemotherapy with OLF regimen（ OLF group,26 cases） and LFP regimen（ LFP group,22cases） respectively. The efficacy and the adverse reaction of the two regimens were compared. Results The effective rate was 53.8% in OLF group and 45.5% in LFP group. Median survival time was 9.5 months and 6.3 months for OLF group and LFP group respectively. The main adverse reaction was suppression of bone marrow with reduction of WBC, with no significant difference between the two groups （ P 〉 0. 05 ）. The reaction of gastrointestinal tract was nausea, vomiting and anorexia, with significant difference between the two groups （ P 〈 0. 01 ）. Conclusion The two regimens OLF and LFP have good efficacy in treatment of the patients with advanced gastric carcinoma. The effective rate was not significanly different between the two groups. However, the OLF regimen （oxalipla- tin plus LV and 5-Fu） is effective and safe and the patients receiving it had a better quality of life and increased survival rate. It is deserved to be spread.