沙培林胸腔内灌注在肺癌术中的临床应用及疗效观察

Clinical application and therapeutic efficacy of intrapleural injection of sapylin during the operation of lung cancer

目的探讨沙培林胸腔内灌注在肺癌术中的临床应用。方法随机选取2004年10月至2006年1月我科收治的肺癌手术患者79例,随机分为两组,观察组42例,术中胸腔灌注沙培林5KE;对照组37例,不予沙培林处理。记录术后24h内体温变化情况及24h胸腔引流液的量;观察术后24h胸部疼痛的情况、手术前肝肾功能的状况及术后肝肾功能变化情况。术后平均随访8.5个月,观察两组胸腔积液及胸膜种植灶发生率。结果两组高热发生率、胸腔引流液量、肝肾功能变化差异无显著性(P>0.05);两组的恶性胸腔积液及胸膜种植灶的发生率差异有显著性(P<0.05)。结论术中使用沙培林胸腔内灌注不良反应少,患者耐受性好;恶性胸腔积液及胸膜种植灶的发生率明显减低,值得临床推广使用。

Objective To investigate the clinical application of intrapleural injection of sapylin during the operation of lung cancer. Method Seventy-nine patients diagnosed as lung cancer were divided into 42 eases of observation group and 37 eases of control group. The observation group received intrapleural injection of sapylin. The changes of body temperature and drain of chest cavity within 24 hours after operation were recorded and the chest pain and the changes of the liver and renal functions were observed before and after operation. The patients were followed up for 8.5 months in average after operation to observe the incidence of the pleural effusion and the pleural seeding foci in the two groups. The results were analyzed with SPSS 11.0 and P 〈 0.05, was considered as significant difference between two groups. Results The incidence of high-grade fever, quanlity of drain of chest cavity and the changes of the liver and renal functions presented no significant difference between two groups （P 〉 0.05 ）. However, the incidences of malignant pleural effusion and pleural seeding focus showed statistical difference between the 2 groups. Conclusion Intrapleural injection of sapylin during the operation deserved popularization for clinical application because of few adverse reactions, fine patient＇s toleration, decreased incidences of pleural effusion and pleural seeding focus.