利钠肽的研究进展

Advances in Natriuretic Peptide Study(review)

利钠肽家族作为内分泌激素,能够通过调节心脏和肾脏的功能达到维持机体的内稳态。对利钠肽的最新研究表明,心力衰竭等心脏病患者的利钠肽水平升高,升高的利钠肽提示心血管事件的高危险性,监测利钠肽能够帮助诊断和判断预后。利钠肽能够抑制心肌的过度增殖和纤维化,具有改善心肌梗死和心衰时的心肌重构作用。脑钠肽是一种最重要的利钠肽,它可以作为心衰和其他心血管疾病的重要生物标记物,能够帮助我们了解肺动脉高压和粥样硬化性血管病等心血管疾病的进展。另外,合成的多种利钠肽如nesiritide已经被试验用来治疗急性充血性心衰。针对多种重组利钠肽的多个临床研究还在实验阶段,主要的方向包括它们在心脏手术中对心脏、肾脏的保护作用和抑制心肌重构的作用。

The natriuretic peptide （NP） system is an endocrine system that maintains fluid and pressure homeostasis by modulating cardiac and renal function. NP levels are elevated in patients with heart failure （HF） and other cardiac diseases. They are early warning system to help to identify patients at high risk for cardiac events. Measurement of NPs may be used to aid diagnosis and prognosis. NPs also can exert important anti-proliferative, anti-fibrotic effects to prevent the remodification in the heart with myocardial infarction and advanced HF. Brain natriuretic peptide is an important biomarker in patients with HF and other cardiovascular diseases, such as pulmonary hypertension and atherosclerotic vascular disease. In addition, synthetic NPs such as nesiritide could be used to treat the patients with acutely congestive HF. These Recombinant drugs are also being investigated for myocardial and renal protection in the setting of cardiac surgery and for prevention of cardiac remodeling.