7FONSECA V,ROSENSTOCK J,PATWARDHAN R,et al.Effect of mefformin and roseglitazone therapy in patients with type 2 diabetes mellitus:a randomized controlled trial[J].JAMA,2000,283(13):1695-1702.
8LARGE V,BEYLOT M.Modifications of citric acid cycle activity and gluconeogenesis in streptozotoc in 2 induced diabetes and effect of mefformin[J].Diabetes,1999,48 (6):1251-1257.
9OWEN M R,DORAN E,HALESTRAP A P.Evidence that metformin exerts its antidiabetic effects through inhibition of complex of the mitochondrial respiratory chain[J].Biochem J,2000,348(pt3):607-614.
10OFENSTEIN J P,DOMONGUEZ L J,SOWERS J R,et al.Effect of insulin and mefformin on glucose metabolism in rat vascular smooth muscle[J].Metabolism,1999,48 (11):1357-1360.
5Campbell RK. Glimepiride: role a new sulfonylurea in thetreatmet of type 2 biabetes mellitus. Ann Pharmacother, 1998,32:1044-1049.
6Kramer W, Muller G, Girbig F, et al. Differential interaction ofgllmepiride and glibenclamide with the β-cell sulfonylurea receptor. Ⅱ . Photoaffinity labeling of a 65 Kda protein by [3H]glimepiride . Biochim Biophys Acta, 1994,1191:278-287.
7Muller G, Satoh Y, Geisen K. Extrapancreafic effects of sulfonylureas : a comparison between glimepiride and conventional sulfonylureas. Diabetes Res clin Pract, 1995, 28 (suppl): s115-s121.
8Boer H, Jansen M, Koerts J, et al. Prevention of weight gain in type 2 diabetes requiring insulin treatment. Diabetes Obes Metab, 2004,6 : 114-117.
9[2]Haffner SM,Gonzalez C,Mietnen H,et al.A prospective analysis of the HOMA model[J].Diabtetes Care,1996,19(10):1138-1141.
10[3]Isomaa B,Almgren P,Tuomi T,et al.Cardiovascular morbidity and mortality associated with the metabolic syndrome[J].Diabetes Care,2001,24(4):683-689.
