人参皂苷Rg1的溶解特性与脂质体包封率关系的研究

On Solubility of Ginsenoside Rg1 and Liposome Entrapment Efficiency

目的:研究人参皂苷Rg1油-水分配系数与脂质体包封率的关系。方法:测定人参皂苷Rg1的正辛醇-水分配系数、氯仿-水分配系数,人参皂苷Rg1在水、甲醇、乙醇中的溶解度;采用不同的方法制备脂质体并测定包封率。结果:人参皂苷Rg1油-水分配系数低于0.5,在3种溶剂中微溶;几种制备方法所得人参皂苷Rg1脂质体包封率均较低。结论:人参皂苷Rg1油-水分配系数小,不适合制成脂质体。

OBJECTIVE： To study the correlation between the oil- water partition coefficient of the ginsenoside Rgl and liposome entrapment efficiency.METHODS： N-octyl alcohol-water partition coefficient, chloroform - water partition coefficient of ginsenoside Rg1, and its dissolubilities in distilled water, methyl alcohol and ethanol were determined.Different methods were used to prepare ginsenoside Rg1 liposome and its entrapment efficiencies were determined. RESULTS：The oil- water partition coefficient of ginsenoside Rgl was lower than 0.5, and which was slightly soluble in 3 solvents; The liposome entrapment efficiencies of ginsenoside Rg1 prepared by different methods were all low.CONCLUSION： Ginsenoside Rg1 showed low partition coefficient and thus unsuitable to be made into liposome.