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Flt3及其突变与白血病的关系 被引量:3

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出处 《临床荟萃》 CAS 北大核心 2007年第1期65-67,共3页 Clinical Focus
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  • 1Abu-Duhier FM,Goodeve AC,Wilson GA,et al.Genomic structure of human Flt3:implications for mutational analysis[J].Br J haematol,2001,113(4):1076-1077.
  • 2Kelly LM,Liu Q,Kutok JL,et al.Flt3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model[J].Blood,2002,99 (1):310-318.
  • 3Rombouts WJ,Blokland I,Lowenberg B,et al.Biological characteristics and prognosis of adult myeloid leukemia with internal tandem duplications in the Flt3 gene[J].Leukemia,2000,14(4):675-683.
  • 4Kottaridis PD,Gale RE,Frew ME,et al.The presence of a Flt3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenic risk group and response to the first cycle of chemotherapy:analysis of 854 patients from the United Kingdom Medical Reserch Council AML 10 and 12 trials[J].Blood,2001,98(6):1752-1759.
  • 5Kiyoi H,Towatari M,Yokotas S,et al.Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product[J].Leukemia,1998,12 (9):1333-1337.
  • 6Fenski R,Flesch K,Serve S,et al.Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells[J].Br J Haematol,2000,108(2):322-330.
  • 7Yamamoto Y,Kiyoi H,Nakano Y,et al.Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies[J].Blood,2001,97(8):2434-2439.
  • 8Abu-Duhier FM,Goodeve AC,Wilson GA,et al.Identification of novel FLT3 ASP835 mutations in adult acute myeloid leukaemia[J].Br J Haematol,2001,113(4):983-988.
  • 9Minami Y,Yamamoto K,Kiyoi H,et al.Different antiapoptotic pathways between wild-type and mutated FLT3:insights into therapeutic targets in leukemia[J].Blood,2003,102 (8):2969-2975.
  • 10Meierhoff G,Dehmel U,Gruss HJ,et al.Expression of the FLT3 receptor and FLT3 ligand in human leukemia-lymphoma cell lines[J].Leukemia,1995,9(8):1368-1372.

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