腹膜透析液中头孢尼西钠的稳定性考察

Study on Stability of Cefonicid Sodium in Peritoneal Dialysis Solution

目的考察头孢尼西钠在25℃和37℃下与腹膜透析液配伍的稳定性。方法将头孢尼西钠加入腹膜透析液中混合均匀后,用紫外分光光度法在25℃和37℃下于0,1,2,4,6,8h时测定头孢尼西钠的含量,同时记录配伍液的外观变化和pH值。结果头孢尼西钠配伍液外观、pH值及含量均无明显变化。结论在25℃和37℃下0～8h内头孢尼西钠可与腹膜透析液配伍使用。

Objective To study the compatible stability of cefonicid sodium and peritoneal dialysis solution under 25-37℃. Methods Cefonicid was added to the peritoneal dialysis solution and mixed evenly. The content of cefonicid was measured under 25-37℃ at 0, 1, 2, 4, 6, 8 h by UV-chromatography. The changes of the compatible solution and the value of pH were recorded. Results There were no obvious changes in outward appearance, value of pH and the content of cefonicid in the compatible solution. Conclusion Cefonicid can be used compatiblely with peritoneal dialysis solution under 25- 37℃ within 0- 8 h.