降压治疗对老老年高血压患者动态血压节律影响研究

Effect of anti-hypertension treatment on 24h ambulatory blood pressure rhythm in very elderly hypertensive

目的:研究降压治疗对老老年高血压患者动态血压节律的影响。方法:167例老老年高血压患者被随机分为降压治疗组(吲哒帕胺,或培托普利治疗)和安慰剂对照组,对比治疗1年。所有病例在安慰剂洗脱2个月后和治疗1年结束时,分别2次接受24 h动态血压监测(ABPM),并进行统计分析。结果:对照组和治疗组治疗前动态血压各指标比较均无显著性差异,节律为非杓型。治疗组治疗后SBP、SBP-L和PP显著降低(P<0.01),且较对照组显著降低(P<0.01);收缩压夜间下降率(SBPF)和舒张压夜间下降率(DBPF)分别为(5.8±1.98)%、(6.4±2.11)%,较对照组显著下降(P<0.05),动态血压节律呈浅杓型。结论:降压治疗对于减轻老老年高血压患者的靶器官损害可能有重要意义。

Objective： To explore the effect of anti-hypertension about 24 hour ambulatory blood pressure rhythm in very elderly hypertensive. Methods： A total of 167 subjects were divided into two groups by randomization： anti-hypertension treatment group （treated with indapamide or perindopril） and placebo-control group （treated with placebo）, respectively. All subjects were performed twice 24 h ambulatory blood pressure monitoring （ABPM） at after 2 months placebo elution and one year treatment. Results： The blood fluctuating curves of treatment group and control group before treatment were non-dipper. The SBP, SBP-L and PP, DBP-L and MAP significantly decreased （P〈 0.01 or 〈0. 05） , after treatment in anti-hypertension treatment group and more than those of placebo-control group （P〈0. 01）. Fall rate of SBP at night （SBPF） and fall rate of DBP at night （DBPF） in treatment group were more than control group （P〈0.05） . The blood pressure fluctuating curves of treatment group transferred to flat dipper after treatment. Conclusion： Anti-hypertension treatment may be possessed considerable significance for relive target organ damage in very elderly hypertensive.