血清免疫球蛋白含量与慢性牙周炎关系的探讨

Relationship between the contents of serum immunoglobulins and chronic periodontitis

目的:探讨机体全身体液免疫反应与慢性牙周炎的关系。方法:采集36例慢性牙周炎患者和36例牙周健康者静脉血2 m l,采用速率散射比浊法对血清样本中IgG,IgA和IgM的含量进行检测;比较病例组和对照组之间血清免疫球蛋白含量的差异,分析免疫球蛋白含量与牙周状态间的相关性。结果:病例组和对照组血清免疫球蛋白含量无显著性差异(P>0.05);血清免疫球蛋白含量与各项临床参数之间显示也不具有相关性。结论;牙周致病菌的侵袭并未引起慢性牙周炎患者明显的全身体液免疫反应,机体的系统体液免疫反应也不能灵敏地体现牙周炎的严重程度。

Objective： To investigate the relationship between the contents of immunoglobulins in serum and chronic periodontitis. Methods： The peripheral venous blood of 2 ml was sampled from each of 36 patients with chronic periedontitis and 36 subjects with normal periodontal conditions. The contents of immunoglobulin G （IgG）, immunoglobulin A （IgA）, and immunoglobulin M （IgM） in serum were determined by tempo turbldimetry. The differences in the contents of serum immunoglobulins between the patients with chronic periodontitis and normal controls were compared, and the relationship between the contents of serum immunoglobulins and periodontal status was analyzed by Pearson＇s correlation analysis. Results： No significant difference in the contents of serum immunoglobulins was found between the patients with chronic periodontitis and normal controls （ P 〉 0.05 ）, and no significant association was observed between the amounts of IgG, IgA, and IgM in serum and several clinical parameters. Conclusions： The invasion of periodontal pathogen does not provoke systemic humoral immune response in patients with chronic periodntitis. The systematic humoral immune response could not sensitively reflect the severity of periodontitis.