可溶性转铁蛋白受体在慢性肾衰伴缺铁性贫血诊断及治疗中的意义

Significance of soluble transferrin receptor in the diagnosis and treatment of chronic renal failure accompanied by iron deficiency anemia

目的:探讨可溶性转铁蛋白受体(sTfR)在慢性肾功能衰竭(CRF)伴缺铁性贫血诊断及治疗中的意义。方法:对42例CRF患者,20例健康对照者采用血液自动分析法进行血红蛋白(Hb)、红细胞压积(Hct)检测;双吡啶比色法测定血清铁(SI)、总铁结合力(TIBC);双抗体夹心酶联免疫法测定血清铁蛋白(SF);生物素-亲和素-酶联免疫法测定sTfR。结果:sTfR在CRF伴缺铁组明显升高;与CRF不伴缺铁组比较有显著性差异(P<0.01)。结论:血清sTfR含量能更加快速、真实地反映体内铁贮存情况,对患者的诊断、治疗具有重要意义。

Objective： To explore the significance of soluble transferrin receptor （sTiR） in the diagnosis and treatment of chronic renal failure （CRF） accompanied by iron deficiency anemia （IDA）. Methods： Blood autoanalysis, dipyridine colorimctry, enzymelinked immunosorbcnt assay （ELISA）, and biotin-avidin amplified ELISA were performed to determine the levels of hematoglobin and hematocrit, serum iron and total iron binding capacity, serum ferritin, and sTiR in 42 patients and 20 health controls, respectively. Results ：he level of sTiR in patients with CRE accompanied by IRD was significantly higher than that in patients with CRE alone （ P 〈 0.01 ）. Conclusion：The level of serum sTiR can quickly and exactly reflect the condition of iron storage in the body and is helpful in the diagnosis and treatment of CRF.