急性冠状动脉综合征患者妊娠相关血浆蛋白A和白细胞介素6的变化

Relationship between serum pregnancy associated plasma protein-A and interleukin-6 in patients with acute coronary syndrome

目的观察急性冠状动脉综合征(ACS)患者血清妊娠相关血浆蛋白A(PAPP-A)和白细胞介素6(IL-6)水平的变化及其之间的相关性,并探讨其临床意义。方法选择46例ACS患者,其中急性心肌梗死(AMI组)20例、不稳定型心绞痛(UA组)26例,22例稳定型心绞痛(SA组)患者和20例正常对照者,采用ELISA双抗体夹心法检测血清PAPP-A和IL-6水平。结果ACS组PAPP-A和IL-6的浓度显著高于SA组和对照组(P<0.05或P<0.01),后两者之间差异无显著性;ACS患者PAPP-A和IL-6之间存在直线正相关关系(r=0.62,P<0.01)。结论PAPP-A和IL-6是与ACS冠状动脉粥样斑块不稳定相关的血清学指标。

Objective To investigate the changes of serum pregnancy associated plasma protein A （PAPP A）, Interleukin-6 （IL-6）concentrations in various types of coronary heart disease, and clarify their clinical significances. Methods Sixty eight patients with ischemic heart disease were included and allocated into 3 groups based on the findings of coronary angiography： stable angina peetoris group （SA, n = 22）, unstable angina pectoris group （UA, n = 26）, as well as acute myocardial infarction group （AMI, n = 20）. Twenty healthy subjects （according to the results of routine laboratory test, physical examination, and coronary angioplasty） were included in this study as control group. The levels of PAPP A and IL 6 were measured by using ELISA. Results The serum levels of PAPP A and IL-6 in acute phase of UA and AMI increased statistically compared with those in control group and SA （ P 〈 0. 05 and 0.01）. There were no significant differences between control group and SA. The serum level of IL 6 was correlated with the serum level of PAPP A in patients with acute coronary syndrome （ r = 0.62, P 〈 0.01）. Conclusion It is suggested that the serum levels of PAPP A and IL-6 in acute phase of the pathophysiological process increased, probable as a marker of unstable plaque in coronary heart disease.