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对氧磷酯酶1与2型糖尿病心脑血管并发症的关系

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摘要 目的探讨血清对氧磷酯酶1(PON1)活性与2型糖尿病(DM)心脑血管并发症的关系。方法对2型糖尿病心脑血管并发症患者和正常对照组以对氧磷为底物测定血清PON1活性。结果单纯2型糖尿病组PON1活性为(152±67)IU/L,比正常对照组显著降低[(224±89)IU/L,P<0.01],2型糖尿病并发心脑血管病变组PON1活性为(110±46)IU/L,比单纯2型糖尿病组显著降低(P<0.01)。结论PON1活性在单纯2型糖尿病及并发心脑血管病变患者中均显著降低,提示PON1活性的降低参与了糖尿病心脑血管并发症的发生。
作者 尚可 孙亚威
出处 《河北医药》 CAS 2006年第12期1155-1156,共2页 Hebei Medical Journal
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