上皮钙粘蛋白在口腔鳞状细胞癌组织中的表达与临床预后的相关性探讨

Correlative Studies on Expression of E-cadherin in Oral Squamous Cell Carcinoma and Clinical Prognosis

目的:探讨上皮钙粘蛋白的表达量与口腔鳞状细胞癌(SCC)的临床病理学参数及SCC患者的预后之间的关系。方法:采用免疫组织化学染色SABC法检测43例口腔鳞状细胞癌组织标本中的蛋白表达量并分析其与临床指标的关系。结果:上皮钙粘蛋白表达与口腔鳞状细胞癌的病理学分级(P=0.024),浸润类型(P=0.009),淋巴结转移情况(P=0.023)及患者的生存年限(P=0.0146)有着密切的关系,蛋白表达越低,病理分级越高,浸润类型越复杂,出现淋巴结转移同时患者生存时间越短。但是,上皮钙粘蛋白表达与患者的年龄,性别及肿瘤的分化度之间无统计学意义。结论:上皮钙粘蛋白是口腔鳞状细胞癌患者一种极其重要的诊断标志物和可靠的预后因子。

MIANObjective： To investigate the correlation between the E-cadherin expression and clinicopathological parameters, as well as prognosis of the patients with oral squamous cell carcinoma. Methods： The expression of the protein E-cadherin in the surgical specimens of 43 cases with oral squamous cell carcinoma was examined by SABC immunohistochemistry. Results： There was a significant correlation between the level of E- cadherin expression, tumor stage （P=0.024）, invasive pattern （P=0.009） and lymph node metastasis （P=0.023）. No correlation was found in the age （P=0.084）, sex （P= 1.356） and differentiation （P=0.877）. The Kaplan-Meier method demonstrated that the E-cadherin with the low expression had a significantly poorer prognosis compared to the cases with the high expression （P=0.0146）. Conclusion： E-cadherin is an important indicator of clinical diagnosis and prognositic marker for oral SCC patients.