卵巢癌患者血清与腹水HA含量检测的临床意义

Detection of hyaluronic acid in serum and ascites from patients with ovarian carcinoma

目的研究卵巢癌患者血清与腹水透明质酸(hyaluronicacid,HA)含量变化及临床意义。方法采用放射免疫法测定38例卵巢癌患者及42例对照组血清术前及术后HA含量,并测定其中22例恶性肿瘤腹水HA含量。结果恶性卵巢癌组术前血清HA含量显著高于对照组及良性肿瘤组,P=0.003,术后明显下降,手术前后血清HA含量差异有统计学意义,P=0.004;卵巢癌患者低度分化组血清HA含量显著高于中度及高度分化组,P=0.006,腹水HA含量显著高于血清,P=0.008,两者之间呈显著正相关,r=0.82,P=0.030,淋巴结转移组血清HA含量显著高于无淋巴结转移组,P=0.002。结论HA与肿瘤的生物学特性密切相关,其血清及腹水含量对于病情判断及监测具有重要的临床意义。

OBJECTIVE： To investigate the hyaluronic acid （HA） level of serum and ascites in ovarian carcinoma. METHODS： Serum and ascites samples from 38 patients with ovarian carcinoma and 42 control cases were collected ant their HA levels were assayed by radioimmunoassay. RESULTS： HA level of serum in patients with ovarian carcinoma was significantly higher than that in control group and in patients with benign tumors （P = 0. 003） before operation. The HA level before yerafion was significantly higher than that affter operation （P=0. 004）. The serum level of HA in low-differentiated tumors was higher than that in the moderate-differentiated tumors and high-differentiated tumors （P=0. 006）. The HA level of ascites was higher than that of serum （P=0. 008） in malignant tumors and they were significantly correlated with each other （r = 0.82, P = 0. 030）. The serum level of HA in the patients with lymph node metastasis was higher than that without lymph node metastasis （P = 0. 002）. CONCLUSIONS.. HA in serum and ascites expressed higher in ovarian carcinoma than benign group. This investigation reveales that HA is an important diameter reflecting tumor biological characteristics,