小细胞肺癌组织中VEGF和MVD的表达及意义

Expression of VEGF and MVD in small cell lung cancer

目的探讨小细胞肺癌(smallcelllungcancer,SCLC)组织中血管内皮生长因子(vascu-larendothelialgrowthfactor,VEGF)、微血管密度(microvesseldensity,MVD)的表达及其临床意义。方法应用SP法检测48例SCLC标本中的VEGF、MVD的含量,及其与临床生物学特性相关性。同时检测20例正常组织作对照分析。结果48例SCLC中VEGF阳性表达率为81%(39/48),MVD平均为52.82±15.34;VEGF阳性组MVD为54.71±11.12,阴性组为43.63±13.57,两组间差异有统计学意义,P=0.013。肿瘤直径≥3cm、区域淋巴结转移与MVD含量密切相关,P值分别为0.024和0.018;其中VEGF阳性率也高,但差异无统计学意义,P值分别为0.159和0.228。20例正常肺组织中VEGF阳性表达率为15%(3/20),MVD平均为18.23±6.92,均明显低于SCLC,P=0.000。结论SCLC组织中VEGF、MVD有高表达,可作为判断SCLC的生长、转移及预后的指标。

OBJECTIVE： To evaluate the clinical significance of expression of vascular endothelial growth factor （VEGF） and microvessel density （MVD） in small cell lung cancer （SCLC）. METHODS： SP immunohistochemical method was used to detect the expression of VEGF and MVD in 48 cases with SCLC and 20 cases with normal lung tissues, and the correlation between the expression of VEGF and MVD, lymph node metastases and the size of tumor. RESULTS： In all SCLC cases, VEGF positive rate was 81% （39/48）, MVD average value was 52.82 ± 15.34. The MVD value of VEGF positive group was higher than that of VEGF negative group （54.71 ± 11.12 vs 43.63±13.57,P=0. 013）. There was significant correlation between the MVD value and size of tumor （P=0. 024）, lymph node metastasis（P=0. 018）. In 20 normal lung tissnes, VEGF postive rate was 15 % （3/20）, and MVD average value was 18.23±6.92, which were both significantly lower than those in SCLC, P=0. 000. CONCLUSION： The expression of VEGF and MVD in SCLC is high, and may be used as objective indicators of the metastatic potency and the prognosis.