动脉瘤性蛛网膜下腔出血患者血清垂体激素含量变化的动态研究

Dynamical changes of the serum concentration of pituitary hormone in patients with aneurysmal subarachnoid hemorrhage

目的：研究动脉瘤性蛛网膜下腔出血（SAH）患者血清促肾上腺皮质激素（ACTH）、促甲状腺激素（TSH）、卵泡刺激素（FSH）、黄体生成素（LH）、泌乳素（PRL）、生长激素（GH）浓度的动态变化规律。方法：对35例动脉瘤性SAH患者发病后1—3d、7—9d、13—15d血清ACTH、TSH、FSH、LH、PRL、GH进行动态观察，用TCD检测大脑中动脉血流速度（VMCA）。结果：动脉瘤性SAH患者血清ACTH、TSH、FSH、LH、PRL、GH发病后1—3d、7—9d各均值明显高于对照组（P均〈0．05），尤以发病后7．9d变化最明显（P〈0．01）；脑血管痉挛组较非脑血管痉挛组也有明显差异（P〈0．05）。结论：动脉瘤性SAH患者血清ACTH、TSH、FSH、LH、GH、PRL含量与病情演变、脑血管痉挛程度有关。

Objective： To investigate the relationship between the serum concentration of ACTH, TSH, FSH, LH, PRL and GH and the subarachnoid hemorrhage. Methods： The serum concentrations of ACTH, TSH, FSH, LH, PRL and GH at 1-3 days, 7-9 days, and 13-15 days after seizures were detected in 35 patients. The VMCA was de- tected by TCD. Results： All the indexes at 1-3 days, 7-9 days after seizures significantly highered. The indexes at 7-9 days after seizures the mast significantly highered.All the indexes of cerebral vasospasm （CVS） patients were markedly different from those of non-CVS patients. Conclusion： These findings suggest that there is a positive correlation between the serum concentration of ACTH, TSH, FSH, LH, PRL and GH and the symptom of CVS.