川崎病并冠状动脉扩张危险因素分析

Analysis of risk factors for coronary artery lesions in Kawasaki disease

目的:探讨川崎病并发冠状动脉扩张的危险因素。方法:确诊为川崎病的患儿126例,根据超声结果分为冠状动脉扩张组和无冠状动脉扩张组,对其性别、年龄、发热天数、急性期C-反应蛋白、血沉、白蛋白、血清钠离子浓度等资料进行比较分析,并作logistic相关分析。结果:126例川崎病患儿并发冠状动脉扩张者66例(占52.38%),无扩张者60例(占47.62%)。两组患儿年龄、发热天数、白蛋白、血钠(低钠)差异有显著性(P<0.05);多因素Logistic回归分析提示年龄、发热时间、血钠浓度和冠脉扩张密切相关(P<0.05)。结论:川崎病患儿并冠状动脉扩张与患儿年龄小、发热时间长及血钠浓度低密切相关。

Objective：To investigate the risk factors for coronary artery lesions in kawasaki disease. Methods：126 children with kawasaki disease were collected.All of the children were divided into two groups according to the results of echoeardiogram of coronary artery： one group was children with coronary artery lesions （CAL＋） and another group no coronary artery lesions （CAL-）. The parameters studied were sex,age,duration of fever, C-reactive protein（CRP）, erythrocyte sedimentation rate（ESR）, albumine, serum sodium levels and so on.These were examined both in univariate analysis and multiple logistic regression. Results：Amoagthe 126cases,the complication of coronary artery lesions was 66（52. 38%）.Univariate analysis indicated that age,the duration of fever,albumine and low serum sodium had significant differences between the two groups （P〈0.05）. Multiple logistic regression analysis indicated age,durationoffever and low serum sodium concentrationhad close relationship withcoronary artery lesions （P〈0.05）. Conclusion：Age〈 1 year,duration of fever prior to treatment and low serum sodium are independent risk factors for coronary artery lesions.