37例神经精神狼疮的临床分析

目的:对神经精神狼疮(NPLE)的临床表现、辅助检查及预后进行总结。方法:对37例伴中枢神经系统损害的SLE患者进行回顾性分析。结果:①有局灶性症状及癫痫反复发作者预后差;②MRI检查的阳性率高,但定位缺乏特异性;③神经精神狼疮(NPLE)患者的脑脊液(CSF)蛋白升高,尤其是IgG的升高是其主要特点。结论:NPLE患者症状不同预后有明显差异,MRI检查和脑脊液蛋白的测定为NPLE的诊断、治疗提供依据。

Objective：To investigate the symptoms , clinical examinations and prognosis of neuropsychiatric lupus erythematosus （NPLE）. Methods： The clinical data of 37 SLE patients with CNS involvement were retrospectively reviewed in our hospital. Results： ①The prognosis of focal manifestations and repeat epileptic seizures are worse. ②MR imaging provided more sensitive for the diagnosis of disease. ③Increased protein concentration, especially increased IgG in CSF, is the prominent feature of neuropsychiatric lupus erythematosus （NPLE）. Conclusion： The prognosis of NPI.E patients is significantly related to clinical manifestations. MR imaging and measurement of protein in CSF provide support for the diagnosis and therapy of NPLE.