摘要
目的:观察氨磷汀对血液恶性肿瘤化疗患者肝脏保护作用及药物的安全性。方法:将18例血液恶性肿瘤患者合并病毒性肝炎或既往化疗肝脏不能耐受者,分为对照组(单纯化疗)和治疗组(化疗加阿米福汀),作自身前后对照研究,化疗前后监测肝功能,同时观察药物不良反应。结果:化疗相关肝功能损害对照组出现18例,治疗组出现3例(P<0.01)。结论:氨磷汀能明显减少化疗相关的肝功能损害,且不良反应少见。
Objective： To study the protection of hepatic toxicity by amifostine on hematological malignamt patients receiving chemotherapy and its adverse reaction. Methods： Eighten patients were treated by two kinds of treatments one was chemotherapy （control group）, the other was chemotherapy plus amifostine （treatment group）. Liver function was observed before and after chemotherapy. Results： Liver function damage occurred in 3 patients in treatment group and 18 patients in control group （P 〈 0.01 ）. Conclusion： Amifostine can apparently reduce the damage of hepatic function of patients caused by cytotoxicticagens ,its side effect is not obvious.
出处
《现代肿瘤医学》
CAS
2007年第1期79-80,共2页
Journal of Modern Oncology
关键词
氨磷汀
化疗
肝功能
血液恶性肿瘤
amifostine
chemotherapy
hepatic function
hematological malignancy
