血清微量元素、GPDA活性和Hp感染与胃癌发生的相关性

The Relationships of Gastric Cancer with Serum Trace Elements ,Glycyl Proline Dipeptidyl Aminoeptidase and Infected by Helicobacter Pylori

目的探讨血清微量元素、苷氨酰脯氨酸二肽氨基肽酶活性(GPDA)和幽门螺杆菌(Hp)感染与胃癌发生的关系。方法采用幽门螺杆菌粪便抗原检测法(HpSA法)、终点法和速率法,分别检测117例初治前胃癌患者、45例良性胃部疾病患者及40例正常人粪便中的Hp阳性率和血清微量元素Ca、Mg、Fe、Cu、Zn的含量及GPDA活性,并比较分析。结果胃癌患者血清Fe和Cu/Zn含量明显高于正常对照组(均P<0.05),Zn含量显著低于正常对照组(P<0.05),Hp和GPDA阳性率分别为70.9%(83/117)和71.8%(84/117)。Hp、GPDA阳性组Zn含量显著低于阴性组(P<0.05)。结论血清Zn含量降低可能是胃癌发生的癌前因素,Zn含量降低可诱发Hp感染而促发癌变。

Objective To study the relationships of gastric cancer with serum trace elements, glycyl proline dipeptidyl aminoeptidase（GPDA）and infected by helicobaeter pylori（Hp）. Methods Helieobacter pylori positive rate in the stool and serum of GPDA activities and trace elements of calcium ,magnesium,iron ,cuprum and zinc were measured by the methods of the Helicobacter pylori stool antigen（HpSA）and end-point with 117 gastric cancer patients ,45 benign stomach disease and 40 normal people and to analyzed relatively. Results The gastric cancer patients infection rate with Hp and positive rate with GPDA of serum were 70.196 （83/117）and 71.5% （84/117）,and the serum of iron and Cu /Zn were markedly higher than the normal control group（P 〈 0.05）. the concentration of Zn in serum of the gastric cancer group were markedly lower than the normal control group（ P 〈 0.05 ）, the Hp positive group and GPDA positive group were markedly lower than the nositive group too（P 〈0.05）. Conclusion The decrease of Zn level in serum may be a precancerous factor of gastric cancer development which induces Hp infection and hence may lead to the development of gastric cancer.