ki-67在喉鳞状细胞癌组织中的表达及其临床意义

The Expression of ki-67 in LaryngealSquamous Carcinoma and its Clinical Significance

目的探讨ki-67在喉鳞状细胞癌中的表达及临床意义。方法采用免疫组织化学法检测50例喉鳞状细胞癌中ki-67蛋白的表达。另选10例正常喉黏膜标本作为对照组。结果喉癌组织中ki-67总阳性率为60%,高于10例对照组的20%;ki-67的表达与喉癌的临床分期和颈部淋巴结转移有一定关系(P<0.05)。结论i-67可作为反映喉鳞状细胞癌生物学行为的客观参考指标,ki-67可作为评定喉鳞状细胞癌的进展、预测其转移的指标之一。

Objective To study the expression and clinical significance of ki-67 in laryngeal squamous carcinoma. Methods With immunohistoch-emistry,the expressions of ki-67 was measured in the paraffin section of the larynx squamous carcinoma tissue of 50 patients. Results The overall positive rate of ki-67 was 60 %. The expression of ki-67 in squamous cell carcinoma of larynx tissues was higher than those mucosa of laryngeal cavity（P 〈 0.05）;The high expression of ki-67 had some relationships to the clinical staging and the metastasis to cervical lymph nodes （P 〈 0.05）. Conclusion ki-67 is objective marks to estimate the behaviors of squamous cell carcinoma of larynx, ki-67can be used as one of the markers to evaluate the development and predict the metastasis of tumors of patient.