液基薄层细胞学检查及TBS报告系统在宫颈病变筛查中的应用

Study on Liquidbased Thinlayer Cytology and TBS for Cervical Diseases Sceening

目的探讨液基薄层细胞制片术和TBS报告系统在子宫颈病变筛查中的价值。方法随机收集635例患者宫颈脱落细胞液基标本,采用液基薄层细胞制片技术和TBS报告系统诊断,对细胞学诊断阳性病例行阴道镜活检和组织病理学诊断,所有诊断均双盲进行。结果635例中检出100.00%(6/6)的鳞状细胞癌(SCC),检出93.33%(14/15)的高级别鳞状上皮内病变(HSIL),检出91.43%(32/35)的的低级别鳞状上皮内病变。结论液基薄层细胞制片和TBS报告系统对宫颈病变检出阳性率较高,与组织学检查的诊断符合率较高,是临床宫颈病变筛查的好方法。生育年龄段的妇女应定期行液基薄层细胞学筛查。

Objective To study the value of liquidbased thinlayer cytology and TBS for cervical diseases screening. Methods This study screen 635 women from August 2005 to July 2006 in this hospital. The cytologic diagnosis was performed using the Bethesda system （TBS） on the liquidbased thinlayer cytology. The results of cytologic screening compare with the results of histopathologic diagnosis. All the diagnosises were performed in an independent and blinded fashion. Results All cases were able to detect 100.00 % （6/6） of squamous cell carcinoma （SCC）, 93.33 % （14/15） high grade squamous intraepithelial lesions （HSIL）, 91.43%（32/35） low grade squamous intraepithelial lesions （LSIL）. Conclusion The liquidbased thinlayer cytology test and the Bethesda System （TBS） is a sensitive method of cervical cancer sceening. Women ranged 20-51 years old should receive liquidbased cytologic screening regularly.