MCV和RDW测定在地中海贫血和巨幼细胞性贫血中的临床价值

Clinical values of mean corpuscular volume and red cell distribution width in diagnosis of anemia

目的:探讨平均红细胞体积(m ean corpuscu lar volum e,MCV)及红细胞体积分布宽度(red b lood cell volum e d istribution w idth,RDW)对地中海贫血(简称地贫,MD)和巨幼细胞性贫血(简称巨幼贫血,MA)诊断的临床价值。方法:利用血细胞自动分析仪测定不同病因的贫血患者的MCV和RDW值。结果:MD患者,MCV降低,RDW升高,且α-地贫与β-地贫无差异;MA患者,MCV和RDW升高;急性失血性贫血和再生障碍性贫血(ap lastic anem ia,AA)患者,MCV和RDW正常。结论:MCV和RDW红细胞参数,可作为贫血病因诊断及鉴别诊断的参考线索,对地贫和巨幼贫血的诊断和治疗有一定的指导意义。

Aim： The significance of the mean corpuscular volume （MCV） and red cell distribution width （RDW） in the diagnosis of MD and MA is investgated. Methods： The values with MCV and RDW in patients with anemia were determined with a blood cell automatic analyzer. Results： In the patients with Mediterranean anemia （ MD）, MCV dropped, RDW raised, and no differences between α - MD and β - MD; the patients of megaloblastic anemia （MA）, MCV and RDW rose; in the patients with acute lose blood anemia and aplastic anemia （AA）, MCV and RDW were normal. Conclusion： The MCV and RDW of red blood cell parameter can be used as the reference clue to diagnose the causes of anemia and for differential diagnosis; it has certain instructive significance in the diagnosis and treatment of MD and MA.