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转化生长因子β_1基因多态性与哮喘发病关系研究 被引量:2

Study on TGF-β_1 Promoter Polymorphism in Asthmatics
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摘要 目的探讨转化生长因子β1(TGF-β1)基因多态性与哮喘发病之间的关系。方法采用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)结合琼脂糖凝胶电泳方法,检测60例哮喘患者与30例健康对照者基因型。结果哮喘组基因型分布与健康对照组比较有显著性异(P<0.05);哮喘组与健康对照组T等位基因比较有显著性差异(P<0.05)。结论TGF-β1启动子C-509T多态性与哮喘发病可能有一定的相关性。 Objective To investigate the possible relationship between TGF-β1 promoter polymorphism and asthma. Methods Sixty asthmatics and thirty healthy subjects were studied with the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) analysis. Results There were three genotypes (CC,CT,TT) in TGF-β1 promoter in the asthmatics and the healthy control subjects. The genotype frequencies between the asthmatics and the healthy control were significantly different (P〈0.05). The T allele frequencies between the two groups were significantly different(P〈0. 05). Conclusion This study indicates that the TGF-β1 promoter polymorphism is associated with the asthma phenotypes.
出处 《江西医学院学报》 CAS 2006年第6期102-103,106,共3页 Acta Academiae Medicinae Jiangxi
关键词 哮喘 转化生长因子Β1 基因 多态性 asthma TGF-β1 gene polymorphism
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