PTEN在不同临床分期胃癌中的表达

Expression of PTEN in Different Clinical Stages of Gastric Cancer

目的探讨酷氨酸磷酸酶簧白基因（PTEN）与胃癌临床分期之间的相关性，以指导临床对胃癌的诊断，为合理治疗和判断预后提供依据。方法应用免疫组织化学方法检测、108例不同临床分期胃癌中PTEN的表达，以x^2检验及Kendall等级相关检验其相关性。结果108例胃癌病例中，侵及粘膜及牯膜下层12例，PTEN表达阳性串33．3％；便及肌层40例，阳性率30.0％；侵及浆膜层及浆膜外56例，阳性率21.4％。PTEN表达与侵润程度无明显相关性（p〉0．05）。有7个以下区域淋巴结转移28例，阳性率42．8％；7～15个区域淋巴结转移46例，阳性率26．0%；15个以上区域淋巴结转移34例，阳性率11．7％。PTEN表达与区域淋巴结转移有相关性（P〈0．05）。无远处转移72例，阳性串30．6％；有远处转移36例，阳性率16．7％。PTEN表达与远处转移有相关性（P〈0．05）。结论PTEN在不同临床分期胃癌组织中表达不同，分期越晚，PTEN阳性率越低，且PTEN表达与肿瘤转移有明显相关性。

Objective To investigate the relevance between PTEN and the clinical stage of gastric cancer. So to guide the diagnosis and provide the theoretical basis of appropriate treatment and prognosis judgement. Methods Expression of PTEN was examined by immunohistochemistry （SP-method） in 108 cases of gastric＇cancer and the ralationship was tested by Chi-square test and Kendall ＇ s rank correlation. Results The positive rate of the expression of PTEN was 33.3% （4/12in those cases the cancer invaded only in mucosa and sudmucosa,30.0 % （12/40 ）in those it invaded into muscular layer and 21. 4 % （ 12/56）in those into serous membrane, and so there was little relationship between the expression of PTEN and the invasion depth（P〉0. 05）. The positive rate was 42.8% （12/28）in those cases the cancer had transfered to less than 7 lymph nodes,26.0%（12/46）in those to 7-15 lymph nodes and 11. 7 % 14/34 ） in those to more than 15 lymph nodes. The positive rate was 30.6% （22/72）in those cases without distant transfer and 16.7%（6/36） in those with distaut transfer, there was notable relevance between the expression of PTEN and the presence of lymph node and distant metastasis（ P〈0.05）Conclusion The expression of PTEN is different in various clincal Stage of gastric cancer. The positive rate is lower in the later stage. There＇s notable relevance between the expression of PTEN and the metastasis of cancer.