肝硬化CT分级与肝切除术前后肝功能的相关性研究

Relationship between CT grade of liver cirrhosis and liver function curve before and after liver resection

目的:研究肝硬化CT分级与肝切除术前后肝功能恢复能力的相关性。方法:研究59例原发性肝癌手术病人及其CT图像。将术前非肿瘤区肝实质的肝硬化分级,与术前临床肝功能分级、术前、术后生化指标变化曲线进行对比研究。结果:CT分级之间各生化指标的术后峰值或谷底和20 d后的时间区段内,ALT(丙氨酸氨基转移酶)、AST(门冬氨酸氨基转移酶)、ALB(白蛋白)和PAB(前白蛋白)水平有统计学意义;而TBIL(总胆红素)和DBIL(直接胆红素)在C-P分级的A、B级之间有统计学意义。结论:肝硬化CT分级与现有的临床常用的肝储备功能,如C-P分级有互补性,可以作为临床肝癌术前评估肝储备功能和判断预后的重要指标之一。

Objective： Studying the relationship between CT grade of liver cirrhosis and liver function curve before and after liver resection. Methods： 59 cases of hepatectomy had been studied for the patients who were all checked by CT. The grade difference was analyzed by comparing preoperative liver CT grades of non-tumor area and clinical liver function grade, preoperative and postoperative biochemical index change curve. Results： The differences between CT grades 1, 2 and 3 in peak and bottom values of ALT, AST, ALB and PAB within 20 days after operation were statistically significant（P〈0.05）, whereas the differences between C-P grades A and B in peak value of TBIL, DBIL and PAB were statistically significant （P〈0.05）. Conclusion： CT grade of liver parenchyma may be one ot important radices avaltable. They are very helpful for diagnosis of liver cirrhosis and assessment of liver reserve function before hepatectomy and for Prognosis. The techniques and C-P grade of liver function are complemented each other.