毒液中富含半胱氨酸分泌蛋白的研究进展

Progress on the Study of Venom-derived CRISPs

富含半胱氨酸分泌蛋白(Cysteine-richsecretoryprotein,简称CRISP)是一个进化上非常保守的蛋白质家族,它们主要发现于哺乳动物生殖道中,但其功能目前还不清楚.近十几年来的研究发现,CRISPs还广泛存在于一些爬行动物、软体动物的毒液中,有钾、钙离子通道和环核苷酸门控通道阻断活性及前体加工酶等活性.现对近十几年来动物毒液来源的CRISPs的结构和功能及它们所具有的潜在应用价值的研究进行综述.

Cysteine-rich secretory proteins （CRISPs） is a highly conserved protein family in evolution. They are predominantly found in male reproductive tracts of mammal and other organisms. However, their functions remain unknown. In the past ten years, studies have revealed that CRISPs were also widely distributed in venoms of some reptile and mollusc and could block Ca^2＋, K^＋ and cyclic nucleotide-gated ion channels. Besides, they also displayed proteolytic activity. Progresses of several venom-derived CRISPs were reviewed briefly.