血管性认知障碍的相关指标

Markers Related with Vascular Cognitive Impairment

血管性认知障碍是由脑血管危险因素(如高血压、糖尿病和高脂血症等)、明显(如脑梗死和脑出血等)或不明显的脑血管病(如脑白质疏松和慢性脑缺血)引起的从轻度认知障碍到痴呆的一大类综合征。其发病率日益增高,但发病机制尚不明确,也缺乏有效的治疗手段,因此各方面的研究日益受到重视。文章主要从神经心理学、影像学、电生理学、生物学和基因方面对VCI的研究近况进行综述。

Vascular cognitive impairment （VCI） is a main type of syndrome from mild cognitive impairment to dementia, which is caused by cerebrovascular risk factors （eg, hypertension, diabetes, hyperlipemia）, obvious （cerebral infarction and hemorrhage） or unobvious cerebrovascular disease （leukoaraiosis and chronic cerebral ischemia）. Its incidence is increasing, hoverer, its pathogenesis remains uncertain, and effective therapeutic tools are lacking. Taerefore, an increasing attention is being paid to all aspects of studies. This article mainly reviews the recent development in research of netropsychology, imaging, electrophysiology, biology, and gene.