期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

神经营养因子受体Trk小分子激动剂研究进展 被引量：2

Recent Progress in Research on Small Molecule Agonist of Neurotrophic Factor Receptor Trk
原文传递
导出
摘要 神经营养因子作用于Trk受体酪氨酸激酶后能激活细胞内磷酸肌醇3-激酶、细胞外信号调节激酶等信号通路,促进神经元的存活和分化。开发非肽类小分子Trk激动剂以及神经营养因子模拟物,能够在激动Trk受体信号转导的同时避免神经营养因子的诸多缺点,为治疗神经系统疾病提供了新的治疗思路。 Neurotrophic factor activates signal pathways of intracellular phosphoinositide 3-kinase and extracellular signal-regulated kinase after acting on Trk receptor tyrosine kinase,It promotes the survival and differentiation of neurons ,The development of small molecule Trk agonists of non-peptides and neurotrophic factor simulants can avoid a number of shortcomings of neurotrophic factors while agitating trk receptor signal transduction,It may provide a novel therapeutic approach for the treatment of nervous system diseases.
作者 卞雷斯 刘振国 王文安
机构地区 上海交通大学医学院附属新华医院神经内科
出处 《国际脑血管病杂志》 2006年第11期865-869,共5页 International Journal of Cerebrovascular Diseases
关键词 神经营养因子 Trk受体 激动剂 neurotrophic factor Trk receptor agonist
分类号 R741 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献23

  • 1Schmidt RE,Dorsey DA,Beaudet LN,et al.Effect of NGF and neurotrophin-3 treatment on experimental diabetic autonomic neuropathy.J Neuropathol Exp Neurol,2001,60:263-273.
  • 2Bruno MA,Clarke PB,Seltzer A,et al.Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA.J Neurosci,2004,24:8009-8018.
  • 3Wilkie N,Wingrove PB,Bilsland JG,et al.The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors.J Neurochem,2001,78:1135-1145.
  • 4Hashimoto R,Takei N,Shimazu K,et al.Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons:an essential step for neuroprotection against glutamate excitotoxicity.Neuropharmacology,2002,43:1173-1179.
  • 5Hernandez CM,Terry AV Jr.Repeated nicotine exposure in rats:effects on memory function,cholinergic markers and nerve growth factor.Neuroscience,2005,130:997-1012.
  • 6Hur JY,Lee P,Kim H,et al.(-)-3,5-Dicaffeoyl-muco-quinic acid isolated from Aster scaber contributes to the differentiation of PC12cells:through tyrosine kinase cascade signaling.Biochem Biophys Res Commun,2004,313:948-953.
  • 7Bachs A,Rabin SJ,Del Fiacco M,et al.Gangliosides prevent excitotoxicity though activation of TrkB receptor.Neurotox Res,2002,4:225-234.
  • 8Mallei A,Rabin SJ,Mocchetti I.Autocrine regulation of nerve growth factor expression by Trk receptors.J Neurochem,2004,90:1085-1093.
  • 9Duchemin AM,Ren Q,Mo L,et al.GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain.J Neurochem,2002,81:696-707.
  • 10Kakinoki B,Sekimoto S,Yuki S,et al.Orally active neurotrophin-enhancing agent protects against dysfunctions of the peripheral nerves in hyperglycemic animals.Diabetes,2006,55:616-621.

同被引文献27

  • 1张平,苏立凯,王德超,赵永晨,李晓芳,杨章群,崔秀艳.大黄素甲醚对脑缺血再灌注损伤大鼠的保护作用(英文)[J].中国临床康复,2005,9(13):240-242. 被引量：1
  • 2周健,孙克华.神经损伤后的再生与神经营养因子[J].中国微侵袭神经外科杂志,2006,11(1):36-38. 被引量：10
  • 3Zhai H, Nakatsukasa M, Mitsumoto Y, et al. Neurotrophic effects of talaumidin, a neolignan from aristolochia arcuata, in primary cultured rat cortical neurons [J]. Planta Med, 2004, 70 (7): 598-602.
  • 4Alvarez XA, Cacabelos R, Laredo M, et al. A 24 - week, double - blind, placebo - controlled study of three dosages of Cerebrolysin in pa- tients with mild to moderate Alzheimer's disease [ J]. Eur J Neurol, 2006, 13 (1): 43-54.
  • 5Hempstead BL Dissecting the diverse actions of pro - and mature neuro- trophins [J]. Curr AlzheimerRes, 2006, 3 (1): 19-24.
  • 6Chan YC, Cheng FC, Wang MF. Beneficial effects of different Polygo- hum multiflorum thunb extracts on memory and hippocampus morphology [J]. J Nutrl Sci Vitaminol (Tokyo), 2002, 48 (6) : 491 -497.
  • 7ChenY, Wang M, Rosen RT, et al. 2, 2-Diphenyl-1 -picryl- hydraxyl radical - scavenging active components from Polygonum multiflo- rum thumb [J]. J Agric Food Chem, 1999, 47 (6) : 2226-2228.
  • 8Brewer GJ, Torricelli JR, Evege EK, et al. Optimized survival of hip- pocampal neurons in B27 - supplemented Neurobasal, a new serum - free medium combination [J]. J Neurosci Res, 1993, 35 (5) : 567 - 576.
  • 9Moriyama M, Huang JM, Yang CS, et al. Structure and neurotrophic activity of novel sesqui - neolignans from the pericarps of Illicium fargesii [ J]. Tetrahedron, 2007, 63 (20) : 4243 -4249.
  • 10Tang W, Kubo M, Harada K, et al. Novel NGF- potentiating diter-penoids from a Brazilian medicinal plant, Ptychopetalum olacoides [J]. Bioorg Med Chem Lett, 2009, 19 (3) : 882 -886.

引证文献2

二级引证文献26

国际脑血管病杂志
2006年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部