槐属植物生物碱衍生物施普睿达抗肿瘤作用的研究

Study on antitumor activity of natural alkaloid derivative Sprita from Sophora Linn

目的:对槐属植物生物碱衍生物施普睿达体内抗肿瘤作用进行研究,并通过肝、脾、胸腺指数等多项指标综合考查施普睿达对荷瘤动物免疫机能的影响。方法:将昆明种小鼠移植宫颈癌U14、肉瘤S180和肝癌H22细胞后,腹腔注射施普睿达,观察施普睿达对实体瘤的抑瘤率。结果:施普睿达对3种移植瘤均有明显的抑制作用,最佳抑瘤率分别为U1474.3%、S18073.9%和H2279.3%,对小鼠的肝、脾指数和胸腺指数几乎无影响;而阳性对照药顺铂使小鼠的肝重、脾指数和胸腺指数明显下降。结论:施普睿达具有抑制S180、U14及H22等多种小鼠移植性肿瘤生长的作用,而且不影响荷瘤动物体重及免疫功能,属于低毒的抗肿瘤新药。

Object： To study antitumor activity in vivo of Sprita - a natural alkaloid derivative from Sophora Linn and its effects on immunological function of mice beating tumor by observing the influence to the liver, spleen index and thymus index. Methods： The mice cervical cancer U14 ,sarcoma S180 and liver cancer H22 were selected and implanted in Kun Ming mice. Then the inhibition rate of cancer was observed after Sprita injected. Results： Sprita had obvious anti - tumor activity to the three tumors, inhibition rates were U14 74.3 %, S180 73.9% and H22 79.3 %, respectively, and had little side -effect to liver, spleen index and thymus index. Nevertheless, the positive control drug cisplatin made liver, spleen index and thymus index decrease significantly. Conclusion： Sprita is a low toxic antitumor drug, it can inhibit the tumor growth of S180, U14, H22 and has no influence on the weight and immunological function of mice bearing tumor.