外源性神经生长因子治疗脑梗死的临床观察

Clinical Observations About treating Patients of Cerebral infarction with Exogenous Nerve Growth Factor

目的对不同病程阶段的脑梗死患者使用外源性神经生长因子,通过疗效观察来推测外源性神经营养因子治疗脑梗死最佳时机。方法采用随机分组法,对不同时期脑梗死患者使用外源性神经生长因子,观察疗效。结果急性期使用外源性神经生长因子的脑梗死患者,其神经功能缺损平均减少分数明显高于恢复期使用的患者(P<0.05)。结论外源性神经生长因子有对脑梗死患者急性期病情改善及促进其神经功能缺损恢复的作用,将为缺血性脑血管病提供新的治疗策略。

Objective To find some evidence that can help to deal with cerebral infarction at the best time by treating CI patients with the exogenous nerve growth factor at different stages. Methods Observation the curative effect of the exogenous nerve growth factor was conducted at different time. Results The average decrease of the scores of neurologic impairment for patients who were treated with the exogenous nerve growth factor at acute stage were significantly higher than that for whom treated at convalescence stage （P 〈0. 01）. Conclusion The exogenous nerve growth factor treatment is beneficial to the patients with cerebral infarction at acute stage that is helpful to provide the new strategy for the therapy of ischemic cerebrovascular disease.