固定化金霉素产生菌原生质体转化林可霉素反应模型的研究

Studies on the Reaction Model for the Immobilized Streptomyces aureofacien's Protoplast Used to Convert Lingcomycin

建立了固定化金霉素产生菌金色链霉菌(Streptomyces aurofaciens)原生质体转化林可霉素反应动力学模型并模拟计算了反应过程,模型计算与实验结果有好的一致性。讨论了各反应参数对转化反应的影响,给出了转化率与反应时间的关系式和最大转化率计算式,还对转化反应动力学模型进一步应用进行了讨论。

A reaction kinetic model is proposed for Immobilized S. aurefacien's protoplast used to convert lincomycin, to clindamycin. the simulation result of the model has been given. Effects of various kinetic parameters of the reaction on the conversion rate are given in formula, the formulas which can be used to calculate the maximum conversion rate and the optimal reaction time have been given. The results of model simulation are in good agreement with the exprimental results.