最小成本为目标函数时最优循环量的确定

Determination of Optimum Recirculation Rate with Minimum Cost as a Objective Function

由于超滤无相变,操作条件温和,能耗低等优点,使其在生物医药领域取得日益广泛的应用,尤其在价格昂贵的生物制品等热敏性生物活性物质的分离、浓缩和纯化中显示出极大优越性,已引起人们的广泛重视。然而,超滤优势的充分发挥受到许多因素的制约。在影响超滤的众多操作因素中,保留液循环量即膜面速度是其中最重要的因素之一,特别是当膜应用于中试或工业化生产后。

The equations of calculation the recirculation rate with minimum cost as a objective function in ultrafiltration process have been deduced. Erythromycin broth has been taken as a model solution which has been ultrafiltrated with outer-pressurized or inner-pressurized equipment in 10 to 20L scale. The parameters of membrane characteristic have been calculated with the experimental data. With these parameters the optimum recirculation rate can be determined. The results are 369L/h for outer-pressurized hollow-fiber equipment (2m2) and 353 L/h (0. 353m/s) for the inner-pressurized hollow-fiber equipment (0. 5m2). The methods are of unversal significance and can be used for reference to membrane process.