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^(125)I对体外培养的胶质瘤细胞C-myc、p53基因表达及细胞增殖的影响 被引量：2

The influence of gene expression on C-myc;p53 and cytoproliferation in glioma cells affected by ^(125)I in vitro
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摘要 目的探讨125I对体外培养的胶质瘤细胞SHG-44C-myc、p53基因表达及细胞增殖的影响。方法利用免疫组化技术检测经125粒子放射处理3d后,SHG-44细胞的C-myc蛋白表达与p53蛋白表达水平。结果经1粒、3粒125粒子放射处理3d后,SHG-44细胞C-myc蛋白表达明显减弱,而p53蛋白表达显著增强。二者呈负相关。结论125I可以通过影响C-myc基因与p53基因的表达抑制人脑恶性胶质瘤细胞株SHG-44增殖,从而抑制胶质瘤的生长。 Objective to explore the inhibitive mechanism of ^125Ⅰ on C-mye,p53 and cytoproliferation in ivtro. Method ^125Ⅰinduces the apoptosis by inhibiting C-myc and p53. Result ^125Ⅰ has an inhibitive effect on the proliferation of SHG-44 cell line by means of decrease the gene＇expression of C-myc and Bcl-2. Conclusion By influencing the expressing level of C-myc and p53 genes,^125Ⅰ can inhibit the growth of glioma SHG-44,so it can be used to treat gliomas.
作者 鞠砚 黄海燕 吴焕成 洪新雨 赵刚 于立军 刘勇
机构地区 吉林大学第一医院神经外科 长岭县中医院神经外科 镇莱县医院神经外科
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2006年第6期672-674,共3页 Journal of Apoplexy and Nervous Diseases
基金 吉林省科委资助课题(No.200505229)
关键词 ^125Ⅰ SHG-44细胞株 p53 C MYC GLIOMAS ^125Ⅰ SHG-44 p53 C-myc Gliomas
分类号 R651.1 [医药卫生—外科学]
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参考文献13

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共引文献10

同被引文献30

  • 1黄海燕,洪新雨,齐红,李毅平,赵刚,李柏.^(125)I对脑胶质瘤p16基因的影响[J].中风与神经疾病杂志,2006,23(5):575-578. 被引量：1
  • 2邵文博,宋金龙.^(125)I粒子近距离照射对BEL-7402肝癌细胞增殖和细胞周期的影响[J].中国医学物理学杂志,2005,22(4):567-567. 被引量：9
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中风与神经疾病杂志
2006年 第6期

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