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难治性癫痫的分子遗传学研究进展

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作者 王广新 杨作成
机构地区 中南大学湘雅三医院儿科
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2006年第6期760-762,共3页 Journal of Apoplexy and Nervous Diseases
基金 中南大学湘雅三医院博士化基金资助项目(No.0508)
关键词 难治性癫痫 分子遗传学 慢性神经系统疾病 抗癫痫药物治疗 反复发作 耐药性癫痫 长期缓解 癫痫患者
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献22

  • 1Ferraro TN,Buono RJ. The relationship between the pharmacology of antiepileptie drugs and human gene variation: An overview [J]. Epilepsy Behavior, 2005,7 (1) : 18-36.
  • 2Esch HV,Syrrou M,Lagae L. Refractory photosensitive epilepsy associated with a complex rearrangement of chromosome 2[J]. Neuropediatrics, 2002,33 : 320-323.
  • 3Remy S,Beck H. Molecular and cellular mechanisms of pharmacorcsistance in epilepsy[J]. Brain,2006,129(1 ): 18-35.
  • 4Potschka H, Fedrowitz M, Loscher W. P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain [J]. Neuro Report, 2001,12 (16): 3557- 3560.
  • 5Volk H A. Increased expression of the multidrug resistance[J]. Epilepsy Res, 2004,58 (9) : 24-32.
  • 6丁成云,徐群渊,栾国明,杨慧,王元身.MDR-1和GFAP蛋白在难治性癫痫脑组织的表达[J].中华神经外科杂志,2002,18(4):238-241. 被引量：21
  • 7陈英辉,赵永波,马爱梅,王乃东,呙登俊.难治性癫痫患者脑内MDR1的表达[J].中风与神经疾病杂志,2006,23(1):60-60. 被引量：7
  • 8Siddiqui A, Kerb R, Weale ME, et al. Association of Multidrug Resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1 [J]. N engl J Med, 2003, 348(15): 1442- 1448.
  • 9Hung CC,Tai JJ,Lin CJ ,et al. Complex haplotypic effects of the ABCB1 gene on epilepsy treatment response[J]. Pharmaeogenomics,2005,6(4) :411-417.
  • 10Kim YO, Kim MK, Woo YJ, et al. Single nucleotide polymorphisms in the multidrug resistance 1 gene in Korean epileptics[J]. Seizure, 2006,15 (1) : 67-72.

二级参考文献14

  • 1王学峰,沈鼎烈.难治性癫癎的基础.王学峰,肖波,孙红斌,等,主编.难治性癫.上海:上海科技出版社,2002.1.
  • 2Beaman-Hall CM,Wainer BH,Eves E.Expression of glucocorticoid and mineralocorticoidreceptors in an immortalized hippocampal neuronal cell line.Brain Res,1996,726:141-152.
  • 3Furtinger S,Bettler B,Sperk G.Altered expression of GABAB receptors in the hippocampusafter kainic-acid-induced seizures in rats.Brain Res Mol Brain Res,2003,113:107-115.
  • 4De Sarro G,Palma E,Costa N,et al.Effects of compounds acting on GABAB receptors in thepentylentetrazole kindling model of epilepsy in mice.Neuropharmacology,2000,39:2147-2161.
  • 5Gambardella A,Manna I,Labate A,et al.GABAB receptor 1polymorphism (G1465A) isassociated with temporal lobe epilepsy.Neurology,2003,60:560-565.
  • 6Winterer G,Smolka M,Samochowiec J,et al.Association of EEG coherence and an exonicGABABRI gene polymorphism.Am J Med Genet B Neuropsychiatr Genet,2003,117:51-56.
  • 7Tishler DM,Weinberg KT,Hinton DR,et al.MDR1 gene expression in brain of patients with medically intractable epilepsy[J].Epilepsia,1995,36 (1):1-6.
  • 8Sisodiya SM,Lin WR,Harding BN,et al.Drug resistance in epilepsy:expression of drug resistance proteins in common cause of refractory epilepsy[J].Brain,2002,125 (1):22-31.
  • 9Aronica E,Gorter J,Jansen G,et al.Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy:focal cortical dysplasia and glioneuronal tumors[J].Neuroscience,2003,118 (2):417-429.
  • 10Potschka H,Fedrowitz M,Loscher W.P-Glycoprotein-mediated efflux of phenobarbital,lamotrigine,and felbamate at the bloodbrain barrier:evidence from microdialysis experiments in rats[J].Neurosci Lett,2002,327(3):173-6.

共引文献33

中风与神经疾病杂志
2006年 第6期

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