保心脑胶囊对高脂血症大鼠血脂的影响

The influence of Baoxinnao capsules on hyperlipidemia rat model

目的:观察保心脑及其组方药亚麻酸、红花油预防性给药对高脂乳剂灌胃造成的高脂血症模型大鼠的降血脂作用,并做拆方验证其组方的正确性。方法:将Wistar大鼠分为8组,模型组每天上午连续给药14 d,后7d下午给予高脂乳剂(1 ml/100 g)制造模型,末次灌胃高脂乳剂后禁食12 h。第15天末次给药后2 h,于清醒状态下摘眼球取血,离心取上清送检。结果:保心脑可显著降低高脂血症模型大鼠血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)水平(P<0.01);亚麻酸组、红花油组与模型组相比,红花油组在降低TC、TG和升高HDL-C方面效果较好(P<0.05),亚麻酸组在降低TC和LDL-C方面效果较好(P<0.05),组方后小剂量组显示了协同降脂的优越性。结论:保心脑可明显降低实验性高脂血症大鼠TG、TC、LDL-C,具有降低血脂的作用。组方后降低血脂作用优于单方,组方具有一定的正确性。

Objective.. （1） To study the influence of drug Baoxinnao, linoleic acid and cardy oil on experimental hyperlipidemia rat model. （2） To study drug interaction of linoleic acid and cardy oil in order to observe whether the effect of the mixture is better than single component. Methods： The experimental hyperlipidemia rat model was established by feeding with high lipid emulsions. Drugs were taken orally at certain osages at 10..30 am. for fourteen days. the last seven days, the rat were fed with high lipid emulsions at 6：00 pm in order to establish experimental hyperelipidemia models. After given high lipid emulsions for the last time, fasting diet for twelve hours. On the fifteenth day, after two hours of giving medicine, we obtained rat＇s blood and centrifuged for supernatant. Results： Baoxinnao can significantly decrease the level of TC, TG, LDL-C in serum of hyperlipidemia rat （P 〈0.01）. Compared with hyperlipidemia model rat cardy oil can decreased TC, TG and increase HDL-C （P d0.05） . Linoleic acid can significantly decreased the contents of TC, LDL-C （P d0.05）. The minidose of Baoxinnao indicate the superiority of decreasing blood fat. Conclusion： Baoxinnao can significantly descreased TC, TG, LDL-C of hyperlipemia model rat. The complex is better than the single-component in decreasing blood fat.