高脂饮食在糖尿病大鼠心肌细胞凋亡中的作用及机制研究
摘要
目的:观察高脂饮食条件下,糖尿病大鼠心肌细胞中脂质沉积及心肌细胞凋亡情况。方法:以高脂喂养糖尿病大鼠为研究对象,分别观察糖尿病组和对照组 NO、NEPA、TG、TC、LDL、HDL、TC、心肌 iNOS、心肌细胞凋亡百分率和脂质在心肌细胞中沉积情况。结果:糖尿病组血糖、NO、NEFA、TG、TC、心肌 iNOS、心肌细胞凋亡百分率明显高于对照组,有统计学意义;病理学检查发现,糖尿病组大鼠心肌细胞中有大量脂质沉积。结论:高脂喂养可导致糖尿病大鼠心肌细胞中沉积大量脂质,同时出现心肌凋亡增加。
出处
《新疆医学》
2006年第6期13-16,共4页
Xinjiang Medical Journal
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