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钩虫抗凝血肽的研究现状 被引量：6

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作者 彭礼飞 王会兰 邓莉 戴世忠
机构地区 广东医学院寄生虫学教研室
出处 《广东医学院学报》 2006年第6期624-627,共4页 Journal of Guangdong Medical College
基金 广东省自然科学基金项目资助(NO04011381)
关键词 钩虫 抗凝血肽 综述文献
分类号 R973.2 [医药卫生—药品]
  • 相关文献

参考文献23

  • 1STASSENS P,BERGUM P W,GANSEMANS Y,et al.Anticoagulant repertoire of the hookworm Ancylostoma caninum[J].Pro Natl Acad Sci USA,1996,93(5):2149-2154.
  • 2HARSSION L M,NERLINGER A,BUNGIRO R D,et al.Molecular characterization of Ancylostoma inhibitors of coagulation factor Xa.Hookworm anticoagulant activity in vitro predicts parasite bloodfeeding in vivo[J].J Biol Chem,2002,277(8):6223-6229.
  • 3MIESZCZANEK J,HARRISON L M,VLASUK G P,et al.Anticoagulant peptides from Ancylostoma caninum are immunologically distinct and localize to separate structures within the adult hookworm[J].Mol Biochem Parasitol,2004,133(2):319-323.
  • 4DeL VALLE A,JONES B F,HARSSION L M,et al.Isolation and molecular cloning of a secreted hookworm platelet inhibitor from adult Ancylostoma caninum[J].Mol Biochem Parasitol,2003,129(2):167-177.
  • 5CAPPELLO M,CLYNE L P,McPHEDRAN P,et al.Ancylostoma factor Xa inhibitor:partial Purification and its identification as a major hookworm-derived anticogulant in vitro[J].J Infect Dis,1993,167(6):1474-1477.
  • 6CAPPELLO M,VLASUK G P,BERGUM P W,et al.Ancylostoma caninum anticoagulant peptide:a hookworm-derived inhibitor of human coagulation factor Xa[J].Proc Natl Acad Sci USA,1995,92(13):6152-6156.
  • 7MIESZCZANEK J,HARRISON L M,CAPPELLO M.Ancylostoma ceylanicum anticoagulant peptide-1:role of the predicted reactive site amino acid in mediating inhibition of coagulation factors Xa and Ⅶa[J].Mol Biochem Parasitol,2004,137(1):151-159.
  • 8BUTENAS S,RIBARIK N,MANN K G.Synthetic substrates for human factor Ⅶa and factor Ⅶa-tissue factor[J].Biochemistry,1993,32(26):6531-6538.
  • 9UGGAN B M,DYSON H J,WRIGHT P E.Inherent flexibility in a potent inhibitor of blood coagulation recombinant nematode anticoagulant protein c2[J].Eur J Biochem,1999,265(2):539-548.
  • 10HARRISON L M,CORDOVA J L,CAPPELLO M.Ancylostoma caninum anticoagulant peptide-5:immunolocalization and in vitro neutralization of a major hookworm anti-thrombotic[J].Mol Biochem Parasitol,2001,115(1):101-107.

二级参考文献23

  • 1Stanssens P,Peter W,Bergum et al.Anticoagulant repertoire of the hookworm Ancylostoma caninum[J].Biochemistry,1996,93:2149-54.
  • 2Duggan BM,Dyson HJ.Inherent flexibility in a potent inhibitor of blood coagulation ,recombinant nematode anticoagulant protein c2[J].Eur J Biochem,1999,265:539-48.
  • 3Bergum PW,Cruikshank A,Maki SL et al.Role of zymogen and activated factor X as scaffolds for the inhibition of the blood coagulation factor VⅡa-tissue factor complex by recombinant nematode anticoagulant protein c2[J].J Biol Chem.2001,276(13):10063-71
  • 4Buddai SK,Toulokhonova L,Bergum PW et al.Nematode anticoagulant Protein c2 reveals a site on factor Xa that is important for macromolecular cubstrate binding to human prothrombinase[J].J Biol Chem,2002,277:26689-98
  • 5Broze GJ.Tissue factor pathway inhibitor[J].Thromb Haemost,1995 ;74:90-3
  • 6Vlasuk GP,Bradbury A,Lopez-Kinninger L et al.Pharmacokinetics and anticoagulant properties of the factor VⅡa-tissue factor inhibitor recombinant Nematode Anticoagulant Protein c2 following subcutaneous administration in man.Dependence on the stoichiometric binding to circulating factor X[J].Thromb Haemost,2003,90(5):803-12
  • 7Vlasuk GP,Bradbury AE,Bergum PW et al.Early clinical evaluation of rNAPc2,a novel inhibitor of blood coagulation factor VⅡa/tissue factor(f VⅡa/TF) [J].J Am Coll Cardiol,1999,33:255-6.
  • 8Freiderich PW,Levi M,Bauer KA et al.Ability of recombinant factor VⅡa to generate thrombin during inhibition of tissue factor in human subjects[J].Circulation.2001,103:2555-9.
  • 9Lee A,Agnelli G,Buller H et al.Dose-reponse study of recombinant factor VⅡa/tissue factor factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement[J].Circulation,2001,104:74-8.
  • 10Lee A,Vlasuk GP.Recombinant nematode anticoagulant protein c2 and other inhibitors targeting blood coagulation factor VⅡa/tissue[J].J Internal Medicine,2003,254:313-21.

共引文献6

同被引文献65

引证文献6

二级引证文献17

广东医学院学报
2006年 第6期

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